Balancing Efficacy and Safety: Discovery and Biological Activity Evaluation of Novel Nitrogen-Containing Fused Heterocyclic Cyclooxygenase Inhibitors

Key Points

• This research aims to discover and evaluate the biological activity of new nitrogen-containing fused heterocyclic compounds as COX inhibitors.
• Evaluated oral bioavailability of compounds in rats at 12.4%
• Assessed toxicity through acute and chronic studies
• Novel compounds exhibited no overt toxicity in tested models
• Promising candidates for future NSAID development identified