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May 10, 2026Journal of Biochemical and Molecular Toxicology0 citations

Promising Synthetic Antioxidants of Dimethyltin(IV) Formulations Derived From 4‐Acylated Edaravone: Design, DFT Assisted Optimized Molecular Structure and Mechanistic Insights into SET Versus HAT Pathways for Antioxidant Activity

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AKAnita KumawatKSKomal SoniSSSanjiv Saxena

Key Points

  • This research aims to explore the antioxidant activity of dimethyltin(IV) complexes derived from 4-acylated edaravone.
  • Calculated molecular structures using DFT-B3LYP functional in Spartan 20 software.
  • Tested antioxidant activity through DPPH assay.
  • Investigated mechanistic pathways involving SET and HAT processes.
  • Dimethyltin(IV) complexes show significant antioxidant activity based on DPPH assay results.
  • Mechanistic insights reveal insights into SET versus HAT pathways for antioxidant action.

Abstract

(Complex 9) were calculated using DFT-B3LYP functional in Spartan 20 computational modelling software. Some representative ligands and their corresponding dimethyltin(IV) complexes were tested for their antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Mechanistic insights into SET versus HAT pathways for antioxidant activity of dimethyltin(IV) formulations of 4-acylated edaravone derivatives have also been studied.

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Cite This Study

Kumawat et al. (2026) studied this question.

synapsesocial.com/papers/6a002087c8f74e3340f9b5b3https://doi.org/10.1002/jbt.70832
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