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May 11, 2026npj Parkinson s Disease1 citationsOpen Access

The biological clock in parkinson’s disease: mechanisms and chronotherapy

HLHong LiuHLHao LingKSKangchao Sun

Key Points

  • This review aims to explore the role of circadian disruption in Parkinson's disease and the impact of chronotherapy.
  • Synthesizes mechanisms of circadian disruption linked to Parkinson's disease.
  • Reviews preclinical and clinical evidence regarding chronotherapy application.
  • Discusses strategies for optimizing treatment efficacy and precision management.
  • Identifies circadian disruption as a significant factor in Parkinson's disease progression.
  • Demonstrates the potential of chronotherapy to enhance treatment outcomes.
  • Suggests reducing medication side effects through precisely timed interventions.

Abstract

Circadian disruption is increasingly recognized as a significant contributor to Parkinson's disease (PD) pathogenesis and progression. From a chronobiological perspective, this review synthesizes relevant mechanisms, preclinical/clinical evidence, and highlights chronotherapy's potential in optimizing PD treatment efficacy, reducing side effects, and enabling precision management.

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a0171473a9f334c28271a2bhttps://doi.org/10.1038/s41531-026-01379-8
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