PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
May 11, 2026npj Parkinson s Disease0 citationsOpen Access

The biological clock in parkinson’s disease: mechanisms and chronotherapy

HLHong LiuHLHao LingKSKangchao Sun

Key Points

  • This review aims to explore the role of circadian disruption in Parkinson's disease and the impact of chronotherapy.
  • Synthesizes mechanisms of circadian disruption linked to Parkinson's disease.
  • Reviews preclinical and clinical evidence regarding chronotherapy application.
  • Discusses strategies for optimizing treatment efficacy and precision management.
  • Identifies circadian disruption as a significant factor in Parkinson's disease progression.
  • Demonstrates the potential of chronotherapy to enhance treatment outcomes.
  • Suggests reducing medication side effects through precisely timed interventions.

Abstract

Circadian disruption is increasingly recognized as a significant contributor to Parkinson's disease (PD) pathogenesis and progression. From a chronobiological perspective, this review synthesizes relevant mechanisms, preclinical/clinical evidence, and highlights chronotherapy's potential in optimizing PD treatment efficacy, reducing side effects, and enabling precision management.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a0171473a9f334c28271a2bhttps://doi.org/10.1038/s41531-026-01379-8
Ask AI
Helpful
Bookmark
Share
View Full Paper