Review demonstrates the potential of deep brain stimulation to manage circadian disruption in Parkinson's disease, suggesting novel pathways for adaptive chronotherapy.
Disruption of sleep and circadian rhythms is a pervasive symptom of Parkinson’s disease with a severe impact on quality of life. We review existing therapies for Parkinson’s disease and circadian disruption (chronotherapies), and we argue that modern deep brain stimulation technology presents a novel treatment pathway for these symptoms—it has the potential to continuously monitor and/or adaptively modulate sleep and circadian rhythms.
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Kirby et al. (2026) studied this question.
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