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August 15, 2026Annals of Indian Academy of NeurologyOpen Access

A Neurologist’s Guide to Deep Brain Stimulation in Parkinson’s Disease

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Authors

RKRanjot KaurDRDivya M. RadhakrishnanRRRoopa Rajan

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Overview

Narrative review outlines deep brain stimulation targets, programming, and outcomes in advanced Parkinson's disease, highlighting essential clinical strategies for multidisciplinary management.

Key Points

  • Provide a comprehensive, clinically focused guide on deep brain stimulation (DBS) for neurologists managing advanced Parkinson's disease with medication-refractory motor complications.
  • Synthesized current clinical evidence on patient selection criteria, multidisciplinary presurgical evaluation, and anatomical target selection.
  • Reviewed surgical workflow, device programming paradigms, long-term management protocols, and emerging technologies such as adaptive stimulation and directional leads.
  • Identified evidence-based stimulation targets, including the subthalamic nucleus, globus pallidus interna, and ventral intermediate nucleus of the thalamus for symptom-specific management.
  • Highlighted recent technological developments in directional leads and sensing-enabled closed-loop systems that improve therapeutic precision.
  • Emphasized the critical role of structured presurgical workups and ongoing device programming in optimizing motor control while minimizing adverse effects.

Cite This Study

Kaur et al. (2026) studied this question.

synapsesocial.com/papers/6a8019bb75c2e31742c85d26https://doi.org/10.4103/aian.aian_93_26
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Deep Brain Stimulation for Parkinson’s Disease—A Narrative Review2025 · 11 citations
  2. 2Neuroscience fundamentals relevant to neuromodulation: Neurobiology of deep brain stimulation in Parkinson's disease2024 · 30 citations
  3. 3Optimizing Outcomes: A Review of Pre- and Post-Surgical Evaluations in Deep Brain Stimulation for Parkinson’s Disease and Essential Tremor2025
  4. 4Tailoring and personalizing deep brain stimulation for Parkinson's disease2024 · 1 citations
  5. 5Deep Brain Stimulation of the Subthalamic Nuclei in Parkinson's Disease: Case Report and MRI/CT Fusion Review2026