Cross-Organ Toxicity and Metabolic Responses to Food Chain-Transferred Nanoplastics: Mechanistic Insights from a Multiomics Perspective

Key Points

• This research aims to explore how food chain-transferred nanoplastics affect metabolic responses and organ toxicity.
• Utilized a multiomics approach to analyze metabolic and toxicological effects.
• Assessed oxidative stress and lipid metabolism disruptions caused by nanoplastics.
• Focused on interactions across different organs.
• Nanoplastics significantly increased oxidative stress levels (p<0.01).
• Lipid metabolism was disrupted, correlating with oxidative stress indicators.
• Findings emphasize the need for improved risk assessment related to nanoplastics.