March 31, 2026Journal of Geriatric Cardiology0 citationsOpen Access
Antithrombotic management in the elderly post-percutaneous coronary intervention: a critical analysis of the PERSEO registry in the context of frailty and evidence-based practice
Key Result
In the PERSEO registry, 75% of elderly patients (≥80 years) post-PCI received prolonged triple antithrombotic therapy, experiencing a 21% incidence of bleeding and 21% all-cause mortality.
Structured PICO
P
Population
Elderly patients (≥80 years) on oral anticoagulation undergoing percutaneous coronary intervention
This critical analysis highlights a concerning disconnect between contemporary clinical practice and evidence-based guidelines, as frail elderly patients frequently receive inappropriately prolonged triple antithrombotic therapy post-PCI, leading to high rates of bleeding and mortality.
Limitations
- Registry data inherently suffer from confounding by indication
- Treatment selection occurs at operator discretion, precluding definitive conclusions about comparative effectiveness