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May 13, 2026Inorganic Chemistry Frontiers0 citationsOpen Access

Binding Azaphilic Copper Radioisotopes with All-Nitrogen Macrocycles for Cancer Theranostics

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SFSara FranchiMAMattia AstiNMNóra May

Key Points

  • This research aims to develop chelators for stable copper radioisotope complexes to enhance cancer theranostics.
  • Synthesis of azaphilic macrocyclic chelators
  • Evaluation of copper radioisotope binding affinity
  • Assessment of radiopharmaceutical stability
  • Demonstrated high thermodynamic stability of copper complexes
  • Showed enhanced kinetic inertness for prolonged efficacy
  • Improved imaging and therapy outcomes in cancer models

Abstract

Copper radioisotopes constitute a true theranostic family, enabling cancer imaging and therapy with chemically identical metal-based radiopharmaceuticals. Developing chelators that provide copper complexes combining high thermodynamic stability, kinetic inertness, and...

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Cite This Study

Franchi et al. (2026) studied this question.

synapsesocial.com/papers/6a03cbbe1c527af8f1ecf6fahttps://doi.org/10.1039/d6qi00856a
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