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May 13, 2026Green Chemistry0 citations

Multi-substrate conversion synchronous cofactor-regeneration for efficient natural product biosynthesis

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CLChaofeng LiShanghai Jiao Tong UniversityYWYeyun WuThe Synergetic Innovation Center for Advanced MaterialsFGFei GuNantong University

Key Points

  • The research aims to enhance the efficiency of natural product biosynthesis by addressing the issues of cofactor regeneration.
  • Proposed a multi-substrate conversion approach for efficient cofactor regeneration.
  • Analyzed redox cofactors as electron mediators in biosynthesis processes.
  • Evaluated the impact of sacrificial agents on atomic economy and by-product generation.
  • Demonstrated improved efficiency in the synthesis of natural products.
  • Reduced unwanted by-products associated with traditional sacrificial agents.

Abstract

Redox cofactors are pivotal electron mediators in natural product biosynthesis, yet the sacrificial agents required for their regeneration compromise atomic economy and generate unwanted by-products. Herein, we propose a multi-substrate...

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a03cbe01c527af8f1ecfa0fhttps://doi.org/10.1039/d6gc01315e
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