Comment on Rao et al. The Oncological Outcome of Postoperative Radiotherapy in Patients with Node-Negative Early-Stage (T1/T2/N0) Oral Squamous Cell Carcinoma and Perineural Invasion: A Meta-Analysis. Cancers 2025, 17, 862

Key Points

• The aim is to evaluate the effect of postoperative radiotherapy on oncological outcomes in patients with node-negative early-stage oral squamous cell carcinoma and perineural invasion.
• Conducted a meta-analysis of studies on postoperative radiotherapy and early-stage oral squamous cell carcinoma.
• Focused on patients characterized as T1/T2 with N0 nodes and perineural invasion.
• Analyzed various oncological endpoints such as survival rates.
• Postoperative radiotherapy was associated with improved survival rates in node-negative patients.
• The presence of perineural invasion significantly influenced treatment outcomes and survival rates.