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May 14, 2026Journal of the American Chemical Society2 citations

Ligand-Modulated Cobalt-Catalyzed Alkene Carbocarbonylation Unlocks Aliphatic Ketone Synthesis

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TZTing ZengLRLiangjie RuanZCZhili CuiSoochow University

Key Points

  • The aim is to develop a method for synthesizing aliphatic ketones through cobalt-catalyzed alkene carbocarbonylation.
  • Utilized cobalt as a catalyst for alkene carbocarbonylation
  • Evaluated various ligands and their effects on reaction outcomes
  • Analyzed regio- and chemoselectivity of the produced ketones
  • Achieved excellent functional group compatibility and high selectivity in reactions involving diverse aliphatic ketones.
  • Demonstrated the process's capability for modular access to structurally diverse ketones.

Abstract

, and their derivatives as the electrophiles, thus affording modular access to structurally diverse aliphatic ketones, which might find potential applications in synthetic and medicinal chemistry. Moreover, this protocol is also distinguished by its simple operation, excellent functional group compatibility, and high regio- and chemoselectivity.

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Cite This Study

Zeng et al. (2026) studied this question.

synapsesocial.com/papers/6a0566fba550a87e60a1eec0https://doi.org/10.1021/jacs.6c06343
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