Structure-Based Design of UVRAG-BAX Binding Interface-Targeting Compound Induces Apoptosis and ROS in Breast Cancer Cells

Key Points

• The aim is to identify a compound that targets the UVRAG-BAX binding interface to induce apoptosis in breast cancer cells.
• Utilized structure-based design to identify a lead compound (ZINC000002107582) targeting UVRAG interface.
• Assessed the anticancer effects of the compound in breast cancer cell lines.
• The lead compound significantly induced apoptosis in breast cancer cells.
• Increased levels of reactive oxygen species (ROS) were observed following treatment.