Arginine‐Enriched Oral Nutritional Supplement as an Adjunct to Standard of Care in the Treatment of Recalcitrant Venous Leg Ulcers

(p = 0.024), representing a mean reduction of 32.8% (p = 0.012). Eight patients had reductions in ulcer size, with one patient achieving complete epithelisation. Two patients showed minimal improvement. There were no gastrointestinal side effects reported. Arginine-enriched ONS, when added to compression-centred multimodal care, was associated with clinically and statistically significant reductions in VLU area. Findings support nutritional optimisation-including arginine-enriched ONS-as a pragmatic adjunct for recalcitrant VLUs; larger randomised controlled trials are warranted. Clinical relevance: In malnourished or slow-to-heal VLU patients, a short course of arginine-enriched ONS may accelerate closure and can be delivered alongside routine outpatient wound care and compression.