Engineering Boronic Acid-Integrated Lipid Nanoparticles for Precision Glycan-Mediated Gene Transfer

Key Points

• This research aims to develop lipid nanoparticles that integrate boronic acid for selective gene transfer through glycan recognition.
• Engineered boronic acid-integrated tocopherol lipids with specific glycan-recognizing headgroups.
• Evaluated the ability of these nanoparticles to mediate gene transfer in cells with aberrant glycosylation.
• Demonstrated enhanced cell-selective gene delivery compared to standard lipid nanoparticles.
• Achieved significant gene transfer efficiency in target cells with specific glycan expressions.