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Cannabidiol (CBD) acts as an antagonist at the sigma 1 receptor (σ1R) to mitigate the negative effects of NMDA receptor overactivity, thereby enhancing morphine antinociception, diminishing NMDA-mediated seizures, and reducing stroke damage. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 17, 2018Molecular Brain126 citationsOpen Access

Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor

MRMaría Rodríguez-MuñozInstituto Cajal YOYara OnettiInstituto Cajal ECElsa Cortés‐MonteroInstituto Cajal

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Abstract

mice. Thus, CBD displays antagonist-like activity toward σ1R to reduce the negative effects of NMDAR overactivity in the abovementioned experimental situations.

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