ROS-responsive Polyethylenimine-phenylboronic acid-Bovine serum Albumin nanoparticles for targeted siMETTL3 delivery in hepatocellular carcinoma treatment

Key Points

• This research aims to develop ROS-responsive nanoparticles for targeted delivery of siMETTL3 in treating hepatocellular carcinoma.
• Developed nanoparticles using polyethylenimine, phenylboronic acid, and bovine serum albumin.
• Targeted siMETTL3 delivery based on TME-specific ROS responsiveness.
• Evaluated efficacy in hepatocellular carcinoma models.
• Nanoparticles showed specific ROS responsiveness in targeting METTL3.
• Enhanced therapeutic effect with significant reduction in tumor growth rates.
• Improved targeting efficiency compared to conventional delivery systems.