What question did this study set out to answer?

The aim is to explore the potential of VHH antibodies targeting FAPα in cancer treatment.

May 15, 2026Journal of Biomolecular Structure and Dynamics0 citations

Studies on single domain antibodies VHH against FAPα as potential cancer therapeutics

MSManoj K. SabnaniMIT Art, Design and Technology University SBSanket BapatMIT Art, Design and Technology University NMNeeraj MaheshwariMIT Art, Design and Technology University

Key Points

The aim is to explore the potential of VHH antibodies targeting FAPα in cancer treatment.
Development of structurally validated anti-FAPα VHH-Fc candidates.
Optimization of functional properties for enhanced immunotherapy efficacy.
Validated several anti-FAPα VHH-Fc candidates.
Demonstrated functional optimization for targeting stromal cells in solid tumors.

Abstract

stromal cells. Collectively, this work establishes a structurally validated and functionally optimized anti-FAPα VHH-Fc candidates for stromal-targeted immunotherapy in solid tumors.

问 AI

Bookmark

View Full Paper