A Cryo-AF dosing algorithm guided by time-to-pulmonary vein isolation was associated with fewer atypical atrial flutters/tachycardias (8.5% vs 13.5%; P=0.02) compared to a conventional approach.
Cohort (n=400)
Does a Cryo-AF dosing protocol guided by TT-PVI reduce atypical atrial flutters/tachycardias and late PV reconnections in patients undergoing a first-time Cryo-AF?
A TT-PVI-guided dosing algorithm for Cryo-AF reduces long-term atypical atrial arrhythmias and late PV reconnections compared to a conventional approach.
Absolute Event Rate: 8.5% vs 13.5%
p-value: p=.02
BACKGROUND: There are no recommendations on the optimal dosing for cryoablation of atrial fibrillation (Cryo-AF). OBJECTIVE: The purpose of this study was to develop and prospectively test a Cryo-AF dosing protocol guided exclusively by time-to-pulmonary vein (PV) isolation (TT-PVI) in patients undergoing a first-time Cryo-AF. METHODS: ; n = 400) in a nonrandomized fashion. RESULTS: was specifically associated with fewer atypical atrial flutters/tachycardias during long-term follow-up (8.5% vs 13.5%; P = .02) as well as fewer late PV reconnections at redo procedures (5.0% vs 18.5%; P <.001). CONCLUSION: A novel Cryo-AF dosing algorithm guided by TT-PVI can help individualize the ablation strategy and yield improved procedural endpoints and efficiency as compared to a conventional, nonstandardized approach.
Aryana et al. (Fri,) conducted a cohort in Atrial fibrillation (n=400). Cryo-AF dosing protocol guided by time-to-pulmonary vein isolation (TT-PVI) vs. Conventional, nonstandardized approach was evaluated on Atypical atrial flutters/tachycardias during long-term follow-up (p=.02). A Cryo-AF dosing algorithm guided by time-to-pulmonary vein isolation was associated with fewer atypical atrial flutters/tachycardias (8.5% vs 13.5%; P=0.02) compared to a conventional approach.