PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
July 1, 1973Circulation106 citations

Vein Graft Surgery for Coronary Artery Disease

View Full Paper
WSWilliam C. SheldonGRGustavo RincónDEDonald B. Effler

Key Result

Vein graft surgery for severe coronary artery disease was associated with a lower annual attrition rate (4.8% per year) compared to a historical nonsurgical cohort (9.3% per year).

Key Points

  • To evaluate the effectiveness and safety of vein graft surgery in patients with severe coronary artery disease.
  • Surgical intervention performed on 1000 patients with severe coronary artery disease from 1967 to 1970.
  • Follow-up for hospital mortality and myocardial infarction rates during hospitalization.
  • Patients were monitored postoperatively for graft patency and long-term survival over 22 to 60 months.
  • Hospital mortality rate was 4%, with a 5.6% incidence of in-hospital myocardial infarction.
  • 84.2% of patients had at least one patent vein graft in postoperative angiograms.
  • Annual attrition rate was 4.8% per year for surgical patients, compared to 9.3% for nonsurgical patients.

Study Design

Type

Cohort (n=1,469)

Structured PICO

Does vein graft surgery improve survival and symptoms in patients with severe coronary artery disease compared to no surgical treatment?

P
Population
1,469 patients with severe coronary artery disease/obstructions (1,000 surgical patients and 469 historical controls who were potential surgical candidates)
I
Intervention
Myocardial revascularization with vein graft techniques (vein graft surgery)
C
Comparator
No surgical treatment (historical control group from an earlier period)
O
Outcome
Survival (annual rate of attrition) over 4 years of follow-uphard clinical

Vein graft surgery for severe coronary artery disease is associated with improved long-term survival and symptom remission compared to non-surgical management.

Main Result

Absolute Event Rate: 4.8% vs 9.3%

Abstract

One thousand patients were operated upon with vein graft techniques for severe coronary artery obstructions between May 1967 and July 1970, with a hospital mortality rate of 4% and a 5.6% incidence of angiographically confirmed in-hospital myocardial infarctions. Postoperative angiograms, performed in 619 of the survivors, revealed patency of one or more vein grafts in 84.2% of patients, and 82.5% of all grafts were patent in studies performed 1 to 49 months after surgery. The hospital survivors were followed for 22 to 60 months; only three patients were lost to follow-up. The survival curve for this group of patients was compared with that of another group of 469 patients who also had severe coronary artery disease and were potential surgical candidates, but were studied in an earlier period and did not have surgical treatment. The annual rate of attrition for each of the four years of follow-up in the surgical group averaged 4.8% per year (2.5% per year excluding hospital mortality), and 9.3% per year in the nonsurgical group. Remission of symptoms correlated closely with the completeness of revascularization. Myocardial revascularization with vein graft techniques can be accomplished successfully and with low risk in the majority of properly selected patients, resulting in a significant improvement in symptoms, as well as in long-term survival.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Sheldon et al. (1973) conducted a cohort in Severe coronary artery disease (n=1,469). Vein graft surgery vs. No surgical treatment (historical cohort) was evaluated on Annual rate of attrition (mortality). Vein graft surgery for severe coronary artery disease was associated with a lower annual attrition rate (4.8% per year) compared to a historical nonsurgical cohort (9.3% per year).

synapsesocial.com/papers/6a076a1b2edded7c7b8437d5https://doi.org/10.1161/01.cir.48.1s3.iii-184
Ask AI
Helpful
Bookmark
Share
View Full Paper