The reperfusion slope of tissue oxygen saturation (StO2) measured by near-infrared spectroscopy significantly correlated with flow-mediated dilation (r = 0.63, P = 0.003) in healthy young men.
Cross-Sectional (n=20)
Does NIRS-derived StO2 reperfusion rate correlate with ultrasound-derived FMD for assessing vascular endothelial function in healthy young men?
NIRS-derived slope 2 StO2 significantly correlates with FMD, suggesting it can be used as a non-invasive measure of vascular endothelial function.
Effect estimate: r = 0.63
p-value: p=0.003
Vascular impairments at the macro- and microcirculatory levels are associated with increased risk for cardiovascular disease. Flow-mediated dilation (FMD) is currently the most widely used method for non-invasive assessment of vascular endothelial function. Recently, near-infrared spectroscopy (NIRS)-derived measures of tissue oxygen saturation (StO2) have been used to characterize the dynamic response of local tissue perfusion to a brief period of ischaemia. The purpose of the present study was to establish correlations between the reperfusion rate of StO2 and FMD. Ultrasound-derived FMD was quantified after 5 min of distal cuff occlusion of the popliteal artery in 20 healthy young men (26 ± 3 years old). Triplicate measurements of end-diastolic arterial diameter were made every 15 s after cuff release, and FMD response was calculated as the greatest percentage change in diameter from baseline (%FMD). The StO2 was measured using NIRS throughout the duration of each test. Two consecutive FMD tests were performed, separated by 30 min of rest, and were averaged for %FMD and StO2. The %FMD was significantly correlated with the reperfusion slope of StO2 after cuff release (slope 2 StO2; r = 0.63, P = 0.003). In conclusion, the present study established a correlation between slope 2 StO2 and %FMD in healthy young men. These data suggest that NIRS-derived slope 2 StO2 can be used as a measure of vascular endothelial function.
McLay et al. (2015) conducted a cross-sectional in Healthy (n=20). Near-infrared spectroscopy (NIRS) measurement of StO2 reperfusion slope vs. Ultrasound-derived flow-mediated dilation (FMD) was evaluated on Correlation between the reperfusion rate of StO2 and FMD (r = 0.63, p=0.003). The reperfusion slope of tissue oxygen saturation (StO2) measured by near-infrared spectroscopy significantly correlated with flow-mediated dilation (r = 0.63, P = 0.003) in healthy young men.