Isocaloric high-intensity interval training and moderate continuous training were equally effective at improving peak V̇O2 over 3 months in HFpEF (8.7% vs 9.2%, P=0.67).
Observational
Does high-intensity interval training compared to moderate continuous training improve peak oxygen consumption in patients with HFpEF?
Isocaloric high-intensity interval training and moderate continuous training are equally effective at improving peak oxygen consumption in HFpEF over 3 months, with training frequency and duration being more strongly associated with improvement than intensity.
Absolute Event Rate: 8.7% vs 9.2%
p-value: p=0.67
AIMS: Exercise training (ET) is an effective therapy in heart failure with preserved ejection fraction (HFpEF), but the influence of different ET characteristics is unclear. We aimed to evaluate the associations between ET frequency, duration, intensity % heart rate reserve (%HRR) and estimated energy expenditure (EEE) with the change in peak oxygen consumption (V̇O2) over 3 months of moderate continuous training (MCT, 5×/week) or high-intensity interval training (HIIT, 3×/week) in HFpEF. METHODS AND RESULTS: ET duration and heart rate (HR) were recorded with a smartphone application. EEE was calculated using the HR data during ET and the individual HR-V̇O2 relationships during cardiopulmonary exercise testing. Differences between groups and associations between ET characteristics and peak V̇O2 change were assessed with linear regression analyses. Peak V̇O2 improved by 9.2 ± 13.2% after MCT and 8.7 ± 15.9% after HIIT (P = 0.67). The average EEE of 1 HIIT session was equivalent to ∼1.42 MCT sessions and when adjusted for EEE, the mean difference between MCT and HIIT was -0.1% (P = 0.98). For both MCT and HIIT, peak V̇O2 change was positively associated with ET frequency (MCT: R2 = 0.103; HIIT: R2 = 0.149) and duration/week (MCT: R2 = 0.120; HIIT: R2 = 0.125; all P < 0.05). Average %HRR was negatively associated with peak V̇O2 change in MCT (R2 = 0.101; P = 0.034), whereas no significant association was found in HIIT (P = 0.234). Multiple regression analyses explained ∼1/3 of the variance in peak V̇O2 change. CONCLUSION: In HFpEF, isocaloric HIIT and MCT seem to be equally effective over 3 months. Within each mode, increasing ET frequency or duration/week may be more effective to improve peak V̇O2 than increasing ET intensity.
Mueller et al. (Fri,) conducted a observational in Heart failure with preserved ejection fraction (HFpEF). High-intensity interval training (HIIT) vs. Moderate continuous training (MCT, 5x/week) was evaluated on Change in peak oxygen consumption (V̇O2) (p=0.67). Isocaloric high-intensity interval training and moderate continuous training were equally effective at improving peak V̇O2 over 3 months in HFpEF (8.7% vs 9.2%, P=0.67).