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Background: Sepsis-associated liver injury (SALI) is a significant risk factor for mortality in patients with sepsis. Magnesium, as an essential electrolyte, has a correlation with adverse outcomes in critical illness when deficient, yet the therapeutic efficacy of magnesium sulfate in SALI remains undetermined. This study was designed to evaluate the association between magnesium sulfate therapy and prognosis in SALI patients. Method: This retrospective cohort study utilized data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database, with the primary endpoint being 30-day all-cause mortality.Propensity score matching (PSM) achieved covariate balance, Kaplan-Meier survival curves and Cox regression were employed to analyze the magnesium sulfate-mortality relationship in SALI patients. The study results were externally validated using the eICU 2.0 database. Result: = 0.005) indicated that magnesium sulfate treatment was an independent protective factor for 30-day all-cause mortality risk. Conclusion: The use of magnesium sulfate is associated with a reduction in all-cause mortality among SALI patients. Future research should consider individual patient variations to explore its true effectiveness.
Ouyang et al. (Tue,) studied this question.