Nonbonding Ammonium Stabilizing Manganese–Oxygen σ-Bond by Manipulating Spin Electrons to Regulate Enzymatic Activities

Key Points

• The aim is to enhance catalytic performance by stabilizing the manganese-oxygen sigma-bond through spin electron manipulation.
• Investigated the stabilization of manganese-oxygen bonds through spin electron adjustments.
• Assessed cascade catalytic performance in tumor microenvironments (TME) for therapy application.
• Enhanced cascade catalytic performance observed within specific tumor microenvironments.