Construction of two drug-loaded gold nanoclusters@mesoporous polydopamine nanospheres and their synergistic treatment of abdominal aortic aneurysms

Key Points

• The study aims to develop a multifunctional nano delivery system for targeted treatment of abdominal aortic aneurysms.
• Developed a nano delivery system using Au nanorod-cluster and mesoporous polydopamine with c(RGDfK) targeting peptide.
• Evaluated the therapeutic efficacy of the system in treating abdominal aortic aneurysms.
• The novel drug-loaded nanocarrier significantly reduced AAA size compared to controls, p<0.01.
• Improved drug uptake and targeting efficiency demonstrated in in vivo models.