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March 29, 2022Journal of Arrhythmia4 citationsOpen Access

Clinicopathological correlates of out‐of‐hospital cardiac arrests

TLTony LiJYJonathan YapWCWei Qiang Chng

Key Result

Among 933 out-of-hospital cardiac arrest patients, 3.4% survived to hospital discharge, and autopsy findings revealed a cardiac etiology in 92.1% of cases with an uncertain cause of death.

Study Design

Type

Observational (n=933)

Multicenter

Yes

Structured PICO

P
Population
933 out-of-hospital cardiac arrests (OHCAs) admitted to two Singapore tertiary hospitals from April 2010 to May 2012
O
Outcome
Predictors of survival and autopsy findings of those with uncertain cause of deathhard clinical

In out-of-hospital cardiac arrests with uncertain cause of death, cardiac etiology predominates on autopsy.

Limitations

  • Limited to two centers from the Singapore cohort of the PAROS registry
  • Study cohort was from 2010 to 2012 and overall OHCA outcomes have since improved
  • Rate of post mortem evaluation was only 17.4%, potentially leading to selection bias
  • No genetic analysis to identify inheritable causes of sudden cardiac arrest
  • Baseline ECGs were not available for analysis
  • Potential variability in case selection definition and data collection

Abstract

Background: Sudden cardiac arrest with or without sudden cardiac death (SCD) represents a heterogeneous spectrum of underlying etiology but is often a catastrophic event. Despite improvements in pre-hospital response and post-resuscitation care, outcomes remain grim. Thus, we aim to evaluate the predictors of survival in out-of-hospital cardiac arrests (OHCAs) and describe autopsy findings of those with the uncertain cause of death (COD). Methods: This is a subgroup analysis of the Singapore cohort from the Pan Asian Resuscitation Outcome Study which studied 933 OHCAs admitted to two Singapore tertiary hospitals from April 2010 to May 2012. Results: = 6) rounding out the top three causes of demise. Conclusion: OHCA remains a clinical presentation that portends a poor prognosis. Of those with uncertain COD, cardiac etiology appears to predominate from autopsy study. Identification of prognostic factors will play an important role in improving individual-level and systemic-level variables to further optimize outcomes.

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Cite This Study

Li et al. (2022) conducted an observational in Out-of-hospital cardiac arrest (OHCA) (n=933). Out-of-hospital cardiac arrest (OHCA) was evaluated on Survival to discharge. Among 933 out-of-hospital cardiac arrest patients, 3.4% survived to hospital discharge, and autopsy findings revealed a cardiac etiology in 92.1% of cases with an uncertain cause of death.

synapsesocial.com/papers/6a0858591e0fcf4a43e8bbb0https://doi.org/10.1002/joa3.12705
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