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March 29, 2022Journal of Arrhythmia4 citationsOpen Access

Clinicopathological correlates of out‐of‐hospital cardiac arrests

TLTony LiLeiden University Medical CenterJYJonathan YapNational Heart Centre SingaporeWCWei Qiang ChngNational Skin Centre

Key Result

Among 933 out-of-hospital cardiac arrest patients, 3.4% survived to hospital discharge, and autopsy findings revealed a cardiac etiology in 92.1% of cases with an uncertain cause of death.

Study Design

Type

Observational (n=933)

Multicenter

Yes

Structured PICO

P
Population
933 out-of-hospital cardiac arrests (OHCAs) admitted to two Singapore tertiary hospitals from April 2010 to May 2012
O
Outcome
Predictors of survival and autopsy findings of those with uncertain cause of deathhard clinical

In out-of-hospital cardiac arrests with uncertain cause of death, cardiac etiology predominates on autopsy.

Limitations

  • Limited to two centers from the Singapore cohort of the PAROS registry
  • Study cohort was from 2010 to 2012 and overall OHCA outcomes have since improved
  • Rate of post mortem evaluation was only 17.4%, potentially leading to selection bias
  • No genetic analysis to identify inheritable causes of sudden cardiac arrest
  • Baseline ECGs were not available for analysis
  • Potential variability in case selection definition and data collection

Abstract

Background: Sudden cardiac arrest with or without sudden cardiac death (SCD) represents a heterogeneous spectrum of underlying etiology but is often a catastrophic event. Despite improvements in pre-hospital response and post-resuscitation care, outcomes remain grim. Thus, we aim to evaluate the predictors of survival in out-of-hospital cardiac arrests (OHCAs) and describe autopsy findings of those with the uncertain cause of death (COD). Methods: This is a subgroup analysis of the Singapore cohort from the Pan Asian Resuscitation Outcome Study which studied 933 OHCAs admitted to two Singapore tertiary hospitals from April 2010 to May 2012. Results: = 6) rounding out the top three causes of demise. Conclusion: OHCA remains a clinical presentation that portends a poor prognosis. Of those with uncertain COD, cardiac etiology appears to predominate from autopsy study. Identification of prognostic factors will play an important role in improving individual-level and systemic-level variables to further optimize outcomes.

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Cite This Study

Li et al. (2022) conducted an observational in Out-of-hospital cardiac arrest (OHCA) (n=933). Out-of-hospital cardiac arrest (OHCA) was evaluated on Survival to discharge. Among 933 out-of-hospital cardiac arrest patients, 3.4% survived to hospital discharge, and autopsy findings revealed a cardiac etiology in 92.1% of cases with an uncertain cause of death.

synapsesocial.com/papers/6a0858591e0fcf4a43e8bbb0https://doi.org/10.1002/joa3.12705
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