CMR feature tracking revealed significantly impaired left ventricular global longitudinal strain in hypertrophic cardiomyopathy patients compared to healthy controls (-18.9% vs -23.5%, p=0.0001).
Case-Control (n=160)
Does CMR feature tracking strain correlate with circulating cardiac biomarkers (NT-proBNP and hsTnT) in patients with hypertrophic cardiomyopathy?
CMR feature tracking reveals subclinical left ventricular and left atrial dysfunction in HCM patients with normal LVEF, which correlates with elevated cardiac biomarkers.
Absolute Event Rate: -18.9% vs -23.5%
p-value: p=0.0001
Abstract Aims CMR feature tracking strain (CMR-FT) provides prognostic information. However, there is a paucity of data in hypertrophic cardiomyopathy (HCM). We sought to analyze global CMR-FT parameters in all four cardiac chambers and to assess associations with NT-proBNP and cardiac troponin T (hsTnT) in patients with HCM. Methods This retrospective study included 144 HCM patients and 16 healthy controls with CMR at 1.5 T. Analyses were performed on standard steady-state free precession cine (SSFP) CMR data using a commercially available software. Global left ventricular (LV) strain was assessed as longitudinal (LV LAX- GLS), circumferential (LV LAX- GCS) and radial strain (LV LAX- GRS) on long -axis (LAX) and as LV SAX -GCS and LV SAX -GRS on short- axis (SAX). Right ventricular (RV-GLS), left atrial (LA-GLS) and right atrial (RA-GLS) strain were assessed on LAX. Results We found LV LAX -GLS − 18.9 (− 22.0, − 16.0), − 23.5 (− 25.5, − 22.0) %, p = 0.0001), LV SAX -GRS [86.8 (65.9–115.5), 119.6 (91.3–143.7) %, p = 0.001 and LA LAX -GLS LA 2CH -GLS 29.2 (19.1–37.7), LA 2CH -GLS 38.2 (34.3–47.1) %, p = 0.0036; LA 4CH -GLS 22.4 (14.6–30.7) vs. LA 4CH -GLS 33.4 (28.4–37.3) %, p = 0.0033 to be impaired in HCM compared to healthy controls despite normal LVEF. Furthermore, LV and LA strain parameters were impaired in HCM with elevated NT-proBNP and/or hsTnT, despite preserved LVEF compared to HCM with normal biomarker levels. There was a moderate correlation of LV and LA CMR-FT with levels of NT-proBNP and hsTnT. Conclusion CMR-FT reveals LV and LA dysfunction in HCM despite normal LVEF. The association between impaired LV strain and elevated NT-proBNP and hsTnT indicates a link between unapparent functional abnormalities and disease severity in HCM. Graphic abstract Typical CMR-FT findings in patients with hypertrophic cardiomyopathy
Çavuş et al. (Mon,) conducted a case-control in Hypertrophic cardiomyopathy (n=160). CMR feature tracking strain vs. Healthy controls was evaluated on Left ventricular long-axis global longitudinal strain (LVLAX-GLS) (p=0.0001). CMR feature tracking revealed significantly impaired left ventricular global longitudinal strain in hypertrophic cardiomyopathy patients compared to healthy controls (-18.9% vs -23.5%, p=0.0001).
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