A self-reinforcing positive loop of ECM mechanics-mediated macrophage-fibroblast two-cell circuit to exacerbate pulmonary fibrosis: A hypothesis

Key Points

• This research explores how ECM mechanics can create a feedback loop involving macrophages and fibroblasts that worsens pulmonary fibrosis.
• Conceptual framework of a self-reinforcing circuit between macrophages and fibroblasts due to ECM mechanics.
• Literature review focusing on the cellular and mechanical interactions in pulmonary fibrosis.
• Development of a hypothesis to explain exacerbation mechanisms.
• Proposes a new perspective on the role of ECM mechanics in pulmonary fibrosis progression.
• Highlights the interconnectedness between macrophage and fibroblast activities mediated by ECM changes.