The highest quartile of the triglyceride-glucose index was significantly associated with increased odds of hypertension compared to the lowest quartile (OR 4.24; 95% CI 3.49-5.16; P<0.001).
Cross-Sectional (n=15,721)
Yes
Is a higher triglyceride-glucose (TyG) index associated with increased blood pressure in adults with no history of cardiometabolic diseases?
A higher triglyceride-glucose index is strongly associated with increased odds of elevated blood pressure, pre-hypertension, and hypertension in healthy adults.
Effect estimate: OR 4.24 (95% CI 3.49-5.16)
p-value: p=< 0.001
BACKGROUND: Insulin resistance (IR) is an important contributor to the development of hypertension (HTN), and the triglyceride-glucose (TyG) index has been proposed as a simple, reliable marker of IR. This study investigated the association between the TyG index and blood pressure (BP) elevation in a large general population. METHODS: The study enrolled 15,721 adults with no history of cardiometabolic diseases from the 2016-2019 Korea National Health and Nutrition Examination Survey. Participants were classified into quartiles based on the TyG index and BP was categorized as normal BP, elevated BP, pre-HTN, and HTN. The associations of the TyG index with BP categories were assessed using multivariate multinomial logistic regression models with normal BP as the reference group. RESULTS: The mean systolic/diastolic BP and prevalence of HTN increased with the TyG index (P for trend < 0.001). The continuous TyG index had a strong dose-response relationship with increased odds of elevated BP, pre-HTN, and HTN. Compared with the lowest TyG index quartile, the highest TyG index quartile was significantly associated with higher odds of having elevated BP (odds ratio OR, 1.52; 95% confidence interval CI, 1.24-1.87; P for trend < 0.001), pre-HTN (OR, 2.22; 95% CI, 1.95-2.53; P for trend < 0.001), and HTN (OR, 4.24; 95% CI, 3.49-5.16; P for trend < 0.001). CONCLUSION: We found that a higher TyG index was positively associated with the risk of increased BP in normal healthy individuals. This study suggests that the TyG index might serve as a potential predictor of HTN. However, further studies with larger sample sizes and various target populations in longitudinal designs are needed.
Lee et al. (Sat,) conducted a cross-sectional in Normotensive (n=15,721). Highest TyG index quartile vs. Lowest TyG index quartile was evaluated on Hypertension (OR 4.24, 95% CI 3.49-5.16, p=< 0.001). The highest quartile of the triglyceride-glucose index was significantly associated with increased odds of hypertension compared to the lowest quartile (OR 4.24; 95% CI 3.49-5.16; P<0.001).