Aged circulating CD8+ T cells and their secreted factors drive cognitive decline

Key Points

• The study aims to investigate the role of aged circulating CD8+ T cells and their secreted factors in cognitive decline.
• Evaluated the impact of T cell-derived factors on cognitive function in aged subjects.
• Measured specific secreted factors associated with CD8+ T cells.
• Analyzed cognitive performance metrics in relation to T cell activity.
• Cognitive performance declines significantly with increased aged CD8+ T cell activity.
• Specific secreted factors correlate with measurable cognitive decline, suggesting a direct impact.
• Identified potential therapeutic targets from these T cell-derived factors for cognitive rescue.