What question did this study set out to answer?

The aim is to understand how natural polyamines interact with lysozyme and affect its stability and motion.

May 20, 2026Physical Chemistry Chemical Physics0 citations

Investigating the Molecular Mechanism by which Natural Polyamines Alter the Conformational Stability and Dynamics of Lysozyme

MYManisha Yadav VRVijayakumar Rajendran SKSumit Kumar

Key Points

The aim is to understand how natural polyamines interact with lysozyme and affect its stability and motion.
Examined interactions between natural polyamines and hen egg white lysozyme (HEWL)
Analyzed conformational changes and dynamics through experimental techniques
Natural polyamines significantly modify the conformational stability of lysozyme
Interactions lead to altered dynamic behavior of the protein

Abstract

This work focuses on how natural polyamines (PAs), such as putrescine (PUT), spermidine (SPD), and spermine (SPM), interact with hen egg white lysozyme (HEWL) and how these interactions alter its...

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