A higher Magnesium Depletion Score (≥3 vs 0) was not significantly associated with increased odds of COPD after full adjustment for confounders (OR 1.30; 95% CI 0.71-2.38; p=0.384).
Cross-Sectional (n=9,232)
Is a higher Magnesium Depletion Score associated with increased odds of self-reported COPD?
The Magnesium Depletion Score appears to act as a composite marker of overall disease burden rather than an independent risk factor for COPD.
Effect estimate: OR 1.30 (95% CI 0.71-2.38)
p-value: p=0.384
Abstract Introduction/Rationale Magnesium plays a crucial role in musculoskeletal and cardiopulmonary function. The Magnesium Depletion Score (MDS) is a clinical tool that assesses magnesium status based on medication use and comorbidities. While dietary magnesium has been linked to respiratory health, the association between MDS and Chronic Obstructive Pulmonary Disease (COPD) remains underexplored. This study investigates the association between MDS and COPD using NHANES 2017-2020 data, and evaluates whether dietary magnesium intake modifies this relationship. Methods This cross-sectional study utilized data from 9,232 participants. Participants were categorized into four groups based on their MDS (0, 1, 2, ≥3). The outcome of interest was self-reported COPD. Weighted multivariable logistic regression models assessed the association between MDS and COPD, with progressive adjustment for confounders: Model 1 was unadjusted; Model 2 adjusted for age, sex, race, and poverty-income ratio (PIR); Model 3 further adjusted for education, BMI, smoking status, hypertension, diabetes, and cardiovascular disease (CVD). Stratified analyses and interaction tests with dietary magnesium intake were performed. Multiple imputation (MIHEml) corrected missing data, and results were compared with complete case analysis (CCA). Results In the unadjusted model (Model 1), higher MDS was strongly associated with increased odds of COPD (MDS≥3 vs. 0: OR = 5.72, 95% CI: 3.43-9.52, p 0.001). This association was substantially attenuated after adjusting for demographic and socioeconomic factors in Model 2 (MDS≥3 vs. 0: OR = 1.72, 95% CI: 0.97-3.07, p = 0.06) and became non-significant after full adjustment in Model 3 (MDS≥3 vs. 0: OR = 1.30, 95% CI: 0.71-2.38, p = 0.384). Stratified analyses suggested potential effect modification by sex and BMI, with significant associations observed among females and overweight individuals. No significant interaction was found between MDS and dietary magnesium intake on COPD risk. Multiple imputation (MIHEml) and CCA yielded similar results, though MIHEml provided more precise estimates with narrower confidence intervals. Conclusions The strong unadjusted association between MDS and COPD is largely confounded by demographic, socioeconomic, and clinical factors, particularly age and comorbidities. The relationship is robust across subgroups but not significantly modified by dietary magnesium intake. This suggests that the score may act as a composite marker of overall disease burden rather than a specific, independent risk factor for COPD. This abstract is funded by: None
Shore et al. (Fri,) conducted a cross-sectional in Chronic Obstructive Pulmonary Disease (COPD) (n=9,232). Magnesium Depletion Score (MDS) ≥3 vs. MDS 0 was evaluated on Self-reported COPD (OR 1.30, 95% CI 0.71-2.38, p=0.384). A higher Magnesium Depletion Score (≥3 vs 0) was not significantly associated with increased odds of COPD after full adjustment for confounders (OR 1.30; 95% CI 0.71-2.38; p=0.384).