Participants with the highest triglyceride-glucose index category had a significantly higher risk of incident atherosclerotic cardiovascular diseases compared to those with the lowest category (HR 1.61).
Meta-Analysis (n=5,731,294)
Does a higher triglyceride-glucose (TyG) index predict the incidence of atherosclerotic cardiovascular diseases in people without ASCVDs at baseline?
A higher triglyceride-glucose (TyG) index is independently associated with an increased risk of incident ASCVDs, CAD, and stroke in individuals without prior cardiovascular disease, suggesting its potential utility as a risk predictor.
Effect estimate: HR 1.61 (95% CI 1.29-2.01)
p-value: p=<0.001
Abstract Background Insulin resistance has been demonstrated to be involved in the pathogenesis of atherosclerotic cardiovascular diseases (ASCVDs). This study evaluated the association between the triglyceride–glucose (TyG) index, a novel surrogate indicator of insulin resistance, and the incidence of ASCVDs in people without ASCVDs at baseline by performing a meta-analysis. Methods Cohort studies reporting the multivariate-adjusted association between the TyG index and the incidence of ASCVDs were obtained by searching the PubMed and Embase databases. A random-effects model incorporating intra-study heterogeneity was applied to combine the results. Results Eight cohort studies comprising 5,731,294 participants were included in this meta-analysis. The results showed that compared to those with the lowest TyG index category, participants with the highest TyG index category were independently associated with a higher risk of ASCVDs hazard ratio (HR): 1.61, 95% confidence interval (CI) 1.29–2.01, I 2 = 80%, P 0.05). Moreover, participants with the highest TyG index category were independently associated with a higher risk of coronary artery disease [(CAD), HR: 1.95, 95% CI 1.47–2.58, I 2 = 92%, P < 0.001 and stroke (HR: 1.26, 95% CI 1.23–1.29, I 2 = 0%, P < 0.001). Conclusions A higher TyG index may be independently associated with a higher incidence of ASCVDs, CAD, and stroke in people without ASCVDs at baseline.
Ding et al. (2021) conducted a meta-analysis in Atherosclerotic cardiovascular diseases (ASCVDs) (n=5,731,294). Highest TyG index category vs. Lowest TyG index category was evaluated on Incidence of ASCVDs (HR 1.61, 95% CI 1.29-2.01, p=<0.001). Participants with the highest triglyceride-glucose index category had a significantly higher risk of incident atherosclerotic cardiovascular diseases compared to those with the lowest category (HR 1.61).