Key result
Highest triglyceride-glucose index linked to ~61% higher incident ASCVD risk versus the lowest category.
Why the study?
Insulin resistance is involved in the pathogenesis of ASCVDs, but the association between the TyG index, a surrogate indicator of insulin resistance, and incident ASCVDs required evaluation.
Does a higher triglyceride-glucose (TyG) index predict the incidence of atherosclerotic cardiovascular diseases in people without ASCVDs at baseline?
Meta-Analysis (n=5,731,294)
Does a higher triglyceride-glucose (TyG) index predict the incidence of atherosclerotic cardiovascular diseases in people without ASCVDs at baseline?
Effect estimate: HR 1.61 (95% CI 1.29-2.01)
p-value: p=<0.001
A higher triglyceride-glucose (TyG) index is independently associated with an increased risk of incident ASCVDs, CAD, and stroke in individuals without prior cardiovascular disease, suggesting its potential utility as a risk predictor.
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TyG index may refine primary-prevention risk stratification; supports further prospective validation before clinical adoption.
Ding et al. (2021) conducted a meta-analysis in Atherosclerotic cardiovascular diseases (ASCVDs) (n=5,731,294). Highest TyG index category vs. Lowest TyG index category was evaluated on Incidence of ASCVDs (HR 1.61, 95% CI 1.29-2.01, p=<0.001). Participants with the highest triglyceride-glucose index category had a significantly higher risk of incident atherosclerotic cardiovascular diseases compared to those with the lowest category (HR 1.61).
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