Symmetric tethering in chronic ischemic mitral regurgitation was associated with significantly higher indexes of global left ventricular remodeling compared to asymmetric tethering (all p < 0.0001).
Observational (n=92)
Do different tethering patterns (symmetric vs asymmetric) in chronic ischemic mitral regurgitation correlate with distinct degrees of LV remodeling and regurgitant jet characteristics?
Patients with chronic ischemic mitral regurgitation can be classified by tethering pattern, with symmetric tethering associated with significantly worse global and local LV remodeling compared to asymmetric tethering.
p-value: p=<0.0001
Although the mechanism of ischemic mitral regurgitation (MR) is understood, the echocardiographic picture of ischemic MR is not homogeneous. Ninety-two consecutive patients with chronic ischemic MR due to restricted motion were divided into two groups according to tethering pattern: the asymmetric group with predominant posterior tethering of both leaflets (54 patients) and the symmetric one with predominant apical tethering of both leaflets (38 patients). The mitral deformation indexes, LV global (volume, function and sphericity) and local (papillary muscle displacements and regional wall motion score index) remodeling were evaluated. All indexes of global LV remodeling were significantly higher in the symmetric than asymmetric group (all p < 0.0001), such as the posterior and lateral displacement of the anterior papillary muscle (both p < 0.04), the papillary muscle separation and the anterior papillary muscle wall motion index (both p < 0.0001). The origin as well as the direction of the jet was central in all patients of the symmetric group. In the asymmetric one the origin was central in 78% of the cases and arising from the medial commissure in 22% whereas the jet direction was posterior and central in 83% and 17% of patients, respectively. Therefore, it is possible to distinguish at least two subgroups of patients with ischemic MR due to restricted motion on the basis of tethering pattern, different degree of local and global LV remodeling and characteristics of the regurgitant jet.
Eustachio Agricola (2004) conducted an observational in Chronic ischemic mitral regurgitation (n=92). Symmetric tethering pattern vs. Asymmetric tethering pattern was evaluated on Mitral deformation indexes, LV global (volume, function and sphericity) and local remodeling (p=<0.0001). Symmetric tethering in chronic ischemic mitral regurgitation was associated with significantly higher indexes of global left ventricular remodeling compared to asymmetric tethering (all p < 0.0001).