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Psittacosis, also known as “bird fever”, is a zoonotic disease caused by Chlamydia psittaci ( Cps ) infection. Its clinical manifestations are similar to those of many respiratory tract infections and lack specificity, leading to a high risk of missed diagnosis or misdiagnosis, which poses great challenges to clinical treatment. With the advancement of diagnostic techniques, timely detection using targeted next-generation sequencing (tNGS) can provide a reliable basis for the early clinical diagnosis of Cps infection and the formulation of individualized treatment regimens. This paper reports a severe case of Cps pneumonia complicated with multiple organ injuries including acute respiratory failure, rhabdomyolysis, and hepatorenal dysfunction. Clinical pharmacists were involved in treatment regimen optimization, medication monitoring, and patient education. Based on the confirmed diagnosis by tNGS, an individualized anti-infective strategy was formulated according to the pathogen characteristics and the patient’s complications, with simultaneous monitoring of multiple organ functions and adverse drug reactions. This case provides clinical evidence for the individualized treatment of severe Cps pneumonia with multiple organ injuries, and also confirms the critical role of tNGS in the diagnosis of rare pathogens.
Huang et al. (Wed,) studied this question.