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May 22, 2026Pathogens0 citationsOpen Access

Serum Phosphorus Levels and 28-Day Mortality in Bloodstream Infection Patients

Association Between Serum Phosphorus and 28-Day Mortality in Patients with Bloodstream Infection: Potential Prognostic Implication Beyond Renal Function and Clinical Severity

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Authors

NPNingjing PuJXJuan XiongYSYueshan Sun

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Overview

Retrospective cohort study finds higher 28-day mortality in bloodstream infection patients with hyperphosphatemia, suggesting prognostic implications.

Key Points

  • This study investigates the link between serum phosphorus levels and 28-day mortality in bloodstream infection patients, assessing whether this relationship holds after adjusting for other factors.
  • Retrospective cohort study of 214 patients with bloodstream infection.
  • Patients were categorized into hyperphosphatemia (≥2.2 mmol/L) and control (<2.2 mmol/L) groups.
  • Multivariate regression and spline analysis were applied to explore the mortality association.
  • 28-day mortality was higher in the hyperphosphatemia group (80.0% vs. 39.7%, p = 0.005).
  • Hyperphosphatemia was significantly linked to higher mortality (OR = 4.46, 95% CI: 1.36–18.54, p = 0.012) after adjustments.
  • Every 0.5 mmol/L rise in serum phosphorus increased mortality odds by 34% (OR = 1.34, 95% CI: 1.07–1.74, p = 0.01).

Cite This Study

Pu et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff3ecd674f7c03778cebdhttps://doi.org/10.3390/pathogens15050553
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