Patients with newly diagnosed type 2 diabetes had significantly higher mean intima media thickness compared to normoglycemic and prediabetic subjects.
Cross-Sectional (n=167)
Are endothelial dysfunction and intima media thickness related to different carbohydrate disturbances across the glucose continuum?
Newly diagnosed type 2 diabetes is associated with increased intima media thickness compared to normoglycemic and prediabetic subjects, highlighting early macrovascular changes.
Aim: The aim of the present study was to investigate the prevalence of macrovascular complications across different carbohydrate disturbances.Patients and methods: In the study, we included 167 patients, divided them into three age and BMI matched groups – group 1 with obesity without carbohydrate disturbances (n = 66), group 2 with prediabetes (n = 68) and group 3 with newly diagnosed type 2 diabetes (n = 33). Endothelial function was evaluated using EndoPAT, intima media thickness (IMT) was measured on the common carotid artery and ankle-brachial index (ABI) was calculated.Results: The patients with T2D had significantly higher mean IMT than the other two groups. The best predictors of increased IMT were fasting blood glucose followed by age and SBP. ROC-analysis showed that blood glucose on 60 min of OGTT had a very good predictive value for endothelial dysfunction.Conclusions: Patients with newly diagnosed diabetes have increased IMT and a tendency towards higher ABI compared to normoglycemic and prediabetic subjects.
Gateva et al. (2018) conducted a cross-sectional in Carbohydrate disturbances (n=167). Newly diagnosed type 2 diabetes and prediabetes vs. Obesity without carbohydrate disturbances was evaluated on Intima media thickness (IMT), endothelial function, and ankle-brachial index (ABI). Patients with newly diagnosed type 2 diabetes had significantly higher mean intima media thickness compared to normoglycemic and prediabetic subjects.