Key result
Patients with newly diagnosed type 2 diabetes had significantly higher mean intima media thickness compared to normoglycemic and prediabetic subjects.
Why the study?
Are endothelial dysfunction and intima media thickness related to different carbohydrate disturbances across the glucose continuum?
Cross-Sectional (n=167)
Are endothelial dysfunction and intima media thickness related to different carbohydrate disturbances across the glucose continuum?
Newly diagnosed type 2 diabetes is associated with increased intima media thickness compared to normoglycemic and prediabetic subjects, highlighting early macrovascular changes.
Newly diagnosed T2D was associated with higher IMT; hypothesis-generating for IMT as early marker across glucose spectrum, pending prospective data.
Aim: The aim of the present study was to investigate the prevalence of macrovascular complications across different carbohydrate disturbances.Patients and methods: In the study, we included 167 patients, divided them into three age and BMI matched groups – group 1 with obesity without carbohydrate disturbances (n = 66), group 2 with prediabetes (n = 68) and group 3 with newly diagnosed type 2 diabetes (n = 33). Endothelial function was evaluated using EndoPAT, intima media thickness (IMT) was measured on the common carotid artery and ankle-brachial index (ABI) was calculated.Results: The patients with T2D had significantly higher mean IMT than the other two groups. The best predictors of increased IMT were fasting blood glucose followed by age and SBP. ROC-analysis showed that blood glucose on 60 min of OGTT had a very good predictive value for endothelial dysfunction.Conclusions: Patients with newly diagnosed diabetes have increased IMT and a tendency towards higher ABI compared to normoglycemic and prediabetic subjects.
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Gateva et al. (2018) conducted a cross-sectional in Carbohydrate disturbances (n=167). Newly diagnosed type 2 diabetes and prediabetes vs. Obesity without carbohydrate disturbances was evaluated on Intima media thickness (IMT), endothelial function, and ankle-brachial index (ABI). Patients with newly diagnosed type 2 diabetes had significantly higher mean intima media thickness compared to normoglycemic and prediabetic subjects.
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