Why the study?
Is there an association between low-grade inflammation, endothelial activation, and carotid intima-media thickness in patients with type 2 diabetes?
Population
317 subjects aged 50-75, comprising 239 type 2 diabetic patients and 78 healthy control subjects.
Design
Cross-sectional
Authors
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Should not yet inform CVD risk stratification in diabetes; leaves open metabolic syndrome as mediator rather than direct driver of atherosclerosis.
Is there an association between low-grade inflammation, endothelial activation, and carotid intima-media thickness in patients with type 2 diabetes?
Low-grade inflammation and endothelial activation are increased in type 2 diabetes but appear to be features of the metabolic syndrome rather than direct determinants of atherosclerosis as measured by carotid IMT.
Leinonen et al. (2004) studied this question.
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