Key result
Type 2 diabetes mellitus was associated with a significantly higher proportion of carotid plaque, higher Crouse scores, and impaired vascular endothelial function compared to healthy controls (P<0.05).
Why the study?
To investigate the correlation of carotid intima-media thickness with endothelial function and atherosclerosis degree in patients with type 2 diabetes mellitus.
Population
80 individuals including 40 patients with type 2 diabetes mellitus and 40 controls
Comparison
Patients with type 2 diabetes mellitus vs healthy examination controls
Design
Case-control study
Authors
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Supports heightened carotid atherosclerosis and endothelial dysfunction in T2DM; leaves open causality and impact on clinical outcomes or management.
Case-Control (n=80)
No
p-value: p=< 0.05
Type 2 diabetes mellitus is associated with increased carotid IMT and impaired vascular endothelial function, with IMT negatively correlating with FMD, VEGF, and ET-1.
Wang et al. (2019) conducted a case-control in Type 2 diabetes mellitus (n=80). Type 2 diabetes mellitus vs. Healthy individuals without type 2 diabetes mellitus was evaluated on Diagnosed proportion of carotid plaque and Crouse score (p=< 0.05). Type 2 diabetes mellitus was associated with a significantly higher proportion of carotid plaque, higher Crouse scores, and impaired vascular endothelial function compared to healthy controls (P<0.05).
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