Key result
Type 2 diabetes in normotensive patients was associated with significantly decreased carotid artery distensibility and increased atheroma thickness compared to controls, with no difference in IMT.
Why the study?
Are carotid artery intima-media thickness, atheroma thickness, and distensibility altered in normotensive patients with type 2 diabetes compared to non-diabetic controls?
Observational (n=123)
Are carotid artery intima-media thickness, atheroma thickness, and distensibility altered in normotensive patients with type 2 diabetes compared to non-diabetic controls?
Normotensive patients with type 2 diabetes exhibit increased atheroma thickness and reduced arterial distensibility despite normal intima-media thickness, indicating early atherosclerotic changes.
Suggests early carotid changes in normotensive T2D; hypothesis-generating and should not yet alter practice.
This study evaluated carotid artery parameters in normotensive patients with type 2 diabetes compared with non-diabetic control subjects. Using a high-resolution B-mode ultrasound scanner, common carotid artery intima-media thickness (IMT) and carotid tree atheroma thickness were measured in 82 patients with type 2 diabetes and 41 controls. The distensibility of the common carotid artery was calculated using the Reneman equation. Distensibility was significantly decreased and atheroma thickness was significantly increased in the diabetes group. There was no significant difference in IMT between the two groups. Stepwise linear regression analysis revealed an association between common carotid artery distensibility and post-ischaemic dilatation of the brachial artery (a measure of endothelial function), body mass index and diabetes duration in patients with type 2 diabetes. In conclusion, common carotid artery IMT in normotensive patients with type 2 diabetes is comparable to that of control subjects, whereas atheroma thickness is higher and arterial stiffness more pronounced in those with type 2 diabetes, indicating the existence of atherosclerotic changes in normotensive type 2 diabetes patients.
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Charvát et al. (2010) conducted an observational in Type 2 diabetes (n=123). Type 2 diabetes vs. Non-diabetic control subjects was evaluated on Common carotid artery intima-media thickness (IMT), carotid tree atheroma thickness, and distensibility. Type 2 diabetes in normotensive patients was associated with significantly decreased carotid artery distensibility and increased atheroma thickness compared to controls, with no difference in IMT.
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