Key result
Uncontrolled type 2 diabetes mellitus was associated with significantly increased mean intima-media thickness of the right common carotid artery (0.84 mm vs 0.72 mm, p=0.01) compared to controlled diabetes.
Why the study?
The study was conducted to determine carotid intima-media thickness in patients with controlled versus uncontrolled type 2 diabetes mellitus.
Does uncontrolled type 2 diabetes mellitus increase carotid intima-media thickness and arterial diameter compared to controlled type 2 diabetes mellitus?
Observational (n=150)
No
Does uncontrolled type 2 diabetes mellitus increase carotid intima-media thickness and arterial diameter compared to controlled type 2 diabetes mellitus?
Absolute Event Rate: 0.84% vs 0.72%
p-value: p=0.01
Uncontrolled type 2 diabetes mellitus is associated with significantly increased carotid intima-media thickness and arterial diameter compared to controlled diabetes, indicating a higher burden of subclinical atherosclerosis.
Warrants caution for subclinical atherosclerosis in uncontrolled T2DM; leaves open whether tighter control slows IMT progression.
Background: Diabetes mellitus refers to a group of common metabolic disorders that share the phenotype of hyperglycemia. The present study was conducted to determine carotid intima-media thickness in patients of controlled and uncontrolled type 2 diabetes mellitus. Materials & Methods: The present study was conducted on 150 type 2 diabetes mellitus patients (75 in controlled diabetes and 75 in uncontrolled diabetes group) of both genders. All patients underwent carotid doppler of common carotid artery determined by higher resolution B mode ultrasonography using Philips Affinity 70 machine. The total of 3 values was averaged to give mean common carotid intima-media thickness value for each patient. Results: Group I had 40 males and 35 females whereas group II had 45 males and 30 females. The mean diameter of right CCA in group I was 6.4 mm and in group II was 7.3 mm, in left CCA was 6.5 mm and in group II was 6.8 mm, right ICA was 4.5 mm in group I and 4.7 mm in group II and left ICA was 4.6 mm in group I and 4.5 mm in group II. The mean IMT of right CCA in group I was 0.72 mm and in group II was 0.84 mm, in left CCA was 0.74 mm and in group II was 0.87 mm, right ICA was 0.43 mm in group I and 0.48 mm in group II and left ICA was 0.45 mm in group I and 0.54 mm in group II. Conclusion: Authors found increase diameter and thickness of intima media in uncontrolled diabetics as compared to controlled diabetics.
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Rashmi Malik (2019) conducted an observational in Type 2 diabetes mellitus (n=150). Uncontrolled type 2 diabetes mellitus (HbA1c > 7) vs. Controlled type 2 diabetes mellitus (HbA1c ≤ 7) was evaluated on Mean intima-media thickness of the right common carotid artery (p=0.01). Uncontrolled type 2 diabetes mellitus was associated with significantly increased mean intima-media thickness of the right common carotid artery (0.84 mm vs 0.72 mm, p=0.01) compared to controlled diabetes.
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