Key result
Lower-limb but not carotid intima-media thicknesses were independently associated with HbA1C, fasting plasma glucose, and 2-hour post-challenge plasma glucose levels.
Population
40 consecutive middle-aged volunteers aged 37 to 53 years, nonclinical sample
Design
Cross-sectional
Authors
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Suggests site-specific glycemic effects on lower-limb atherosclerosis; hypothesis-generating and should not yet change vascular risk assessment.
Cross-Sectional (n=40)
Single-blind
No
Effect estimate: β coefficient 0.0424 for HbA1C at lower-limb arteries
p-value: p=<0.05
In a middle-aged nonclinical sample, glycemic markers (HbA1c, fasting and post-challenge glucose) are independently associated with lower-limb but not carotid intima-media thickness, suggesting site-specific susceptibility to glycemia.
Ho et al. (2009) conducted a cross-sectional in Atherosclerosis (n=40). Fasting and post-challenge plasma glucose levels was evaluated on Intima-media thickness (IMT) at multiple arterial sites (β coefficient 0.0424 for HbA1C at lower-limb arteries, p=<0.05). Lower-limb but not carotid intima-media thicknesses were independently associated with HbA1C, fasting plasma glucose, and 2-hour post-challenge plasma glucose levels.
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