Key result
Altered glucose metabolism was associated with nearly twice the risk of developing carotid target organ damage compared to normal glucose metabolism (OR 1.920).
Why the study?
Do markers of glycemia (fasting plasma glucose, postprandial glucose, HbA1c) correlate with carotid intima-media thickness in intermediate-risk cardiovascular patients?
Population
427 subjects, aged 35 to 74 years, 55% women, with intermediate cardiovascular risk. Includes 231 with…
Design
Cross-sectional, The individuals performing the different tests were blinded…
Authors
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HbA1c and fasting glucose associations with C-IMT support refined risk assessment in intermediate-risk patients; leaves open prospective validation for events.
Cross-Sectional (n=427)
Do markers of glycemia (fasting plasma glucose, postprandial glucose, HbA1c) correlate with carotid intima-media thickness in intermediate-risk cardiovascular patients?
Odds Ratio: 1.92 (95% CI 1.079–3.415)
p-value: p=0.026
In intermediate-risk cardiovascular patients, fasting plasma glucose and HbA1c are positively associated with carotid intima-media thickness, suggesting an increased risk of subclinical atherosclerosis with metabolic glucose alterations.
Gómez‐Marcos et al. (2016) conducted a cross-sectional in Intermediate cardiovascular risk (n=427). Altered glucose metabolism (prediabetes or diabetes) vs. Normal glucose metabolism was evaluated on Presence of carotid target organ damage (TOD) (OR 1.920, 95% CI 1.079-3.415, p=0.026). Altered glucose metabolism was associated with nearly twice the risk of developing carotid target organ damage compared to normal glucose metabolism (OR 1.920).
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