Key result
Type 2 diabetes was associated with significantly greater superficial femoral artery IMT, popliteal artery IMT, and superficial femoral artery PWCV compared to euglycemic subjects (all P < 0.0001).
Why the study?
Does type 2 diabetes increase intimal-medial thickness and pulse wave conduction velocity in unstenosed lower-limb arteries compared to euglycemic subjects?
Cross-Sectional (n=156)
Does type 2 diabetes increase intimal-medial thickness and pulse wave conduction velocity in unstenosed lower-limb arteries compared to euglycemic subjects?
p-value: p=<0.0001
Type 2 diabetes and metabolic syndrome features are associated with adverse structural and functional changes (increased IMT and PWCV) in unstenosed lower-limb arteries.
Supports hypothesis of diabetes-induced lower-limb arterial remodeling; leaves open whether IMT or PWCV predict limb events.
OBJECTIVE: To compare intimal-medial thickness (IMT) and pulse wave conduction velocity (PWCV) in unstenosed arteries of the lower limb in subjects with and without type 2 diabetes and to determine the contribution of a range of cardiovascular risk factors. RESEARCH DESIGN AND METHODS: IMT and PWCV were determined in lower-limb arteries of 79 subjects with diabetes and 77 euglycemic subjects. Plasma lipids were determined by enzymatic assays, and LDL particle size was measured by gradient gel electrophoresis. Lag time for copper-induced oxidation of LDL was determined. alpha-Tocopherol, retinol, and ascorbate levels were determined by high-performance liquid chromatography, soluble E-selectin by enzyme-linked immunosorbent assay, and fibrinogen and factor VII by automated assays. RESULTS: Subjects with diabetes had greater superficial femoral artery (SFA) IMT, popliteal artery (PA) IMT, and SFA PWCV (all P < 0.0001). In univariate analysis, IMT and PWCV correlated with increased waist-to-hip ratio, triglycerides, and fibrinogen and inversely with HDL cholesterol and LDL size. Ascorbate was inversely associated with IMT, and LDL lag time was inversely correlated with PWCV. Subjects with the greatest number of features of the metabolic syndrome had the highest IMT and PWCV. CONCLUSIONS: Adverse changes in the structure and function of unstenosed lower-limb arteries are present in type 2 diabetes and are associated with features of the metabolic syndrome.
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O’Neal et al. (2003) conducted a cross-sectional in Type 2 diabetes (n=156). Type 2 diabetes vs. Euglycemic subjects was evaluated on Superficial femoral artery (SFA) IMT, popliteal artery (PA) IMT, and SFA PWCV (p=<0.0001). Type 2 diabetes was associated with significantly greater superficial femoral artery IMT, popliteal artery IMT, and superficial femoral artery PWCV compared to euglycemic subjects (all P < 0.0001).
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