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May 24, 2026Cell Reports Medicine0 citationsOpen Access

Lung mucosal and systemic responses at single-cell resolution in an aerosolized Mycobacterium bovis BCG human challenge model

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SLShuailin LiHMHazel MorrisonMDM. D. Duta

Key Points

  • This research aims to explore T cell responses in the lung mucosa and their reactivity to mycobacterial antigens following infection.
  • Utilized an aerosolized Mycobacterium bovis BCG challenge model in humans.
  • Analyzed T cell localization and expansion in lung mucosa at the single-cell level.
  • Validated mycobacterial antigen reactivity using reporter T cells.
  • T cells preferentially localize in the lung mucosa over newly expanded clones.
  • Publicly expanded clones in the lung mucosa demonstrate mycobacterial antigen reactivity.
  • Findings highlight important implications for the design of tuberculosis vaccines.

Abstract

T cells and preferentially localize to the lung mucosa than newly expanded clones. Public expanded clones in the lung mucosa are validated as mycobacterial antigen-reactive using reporter T cells. These findings provide insights into mucosal and systemic immunity post-mycobacterial infection, informing TB vaccine design.

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a12958948a0ea166567192chttps://doi.org/10.1016/j.xcrm.2026.102830
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