Abstract Sarcopenia is a long-term, progressive condition affecting skeletal muscle, characterized by reduced muscle mass, diminished strength, and decreased muscle quality, and poses a significant health challenges in the aging population. It is now recognized as a distinct clinical condition of multifactorial origins. Among its numerous contributors, type 2 diabetes mellitus (T2DM) has emerged as a prominent player. Increasing evidence supports a reciprocal relationship between sarcopenia and T2DM, where hyperglycemia, insulin resistance, chronic inflammation, and mitochondrial dysfunction can accelerate muscle deterioration, while sarcopenia may further impair glucose metabolism. This narrative review explores the complex interrelationship between sarcopenia and T2DM, highlighting risk factors, shared pathophysiological mechanisms, and the importance of integrated strategies for early diagnosis and management in older adults.
Venkitta et al. (Fri,) studied this question.