Galangin improved sperm motility and concentration and reduced oxidative stress and AT1R/NOX2 expression in a rat model of renovascular hypertension compared to untreated controls.
Does galangin improve sperm quality in a rat model of renovascular hypertension?
Galangin ameliorates sperm dysfunction in a rat model of renovascular hypertension by reducing oxidative stress and modulating the renin-angiotensin system.
Renovascular hypertension (RVH) is associated with oxidative stress and impaired reproductive function. Galangin, a polyphenolic compound with antioxidative properties, may mitigate these adverse effects. This study aimed to evaluate the therapeutic effects of galangin on sperm quality in an RVH rat model. Male Sprague–Dawley rats were induced using a two‐kidney, one‐clip (2K‐1C) model by clipping the renal artery. The mice were divided into sham (control), 2K‐1C, 2K‐1C + galangin (30 and 60 mg/kg body weight), and 10 mg/kg losartan groups. Sperm motility and concentration, and body and organ weights were measured. Testicular angiotensin II type 1 receptor (AT 1 R) and NADPH oxidase 2 (NOX2) protein expression and plasma and testicular malondialdehyde (MDA) levels were determined to evaluate oxidative stress. 2K‐1C rats had significantly increased testicular MDA levels and reduced sperm motility and concentration. The 2K‐1C rats also showed upregulated testicular AT 1 R and NOX2 expressions. Galangin reduced oxidative stress and downregulated AT 1 R and NOX2 expression. It also improved sperm quality, as evaluated by sperm motility and concentration, compared to that in the untreated 2K‐1C group. Galangin ameliorates sperm dysfunction in 2K‐1C rats by reducing oxidative stress and modulating the renin–angiotensin system. These findings suggest a potential therapeutic role for galangin in patients with male infertility with renal artery stenosis.
Poasakate et al. (Thu,) conducted a other in Renovascular hypertension and sperm dysfunction. Galangin vs. Sham, untreated 2K-1C, and 10 mg/kg losartan was evaluated on Sperm motility and concentration, oxidative stress markers, and AT1R/NOX2 expression. Galangin improved sperm motility and concentration and reduced oxidative stress and AT1R/NOX2 expression in a rat model of renovascular hypertension compared to untreated controls.